MCL Literature Feed

For younger MCL patients post-transplant, this phase III analysis shows conditional survival improves over time, especially after R-CHOP, providing data for dynamic prognostication and reinforcing intensive induction.

A simulation model using 20 years of real-world data establishes a baseline for lifetime treatment trajectories, crucial for evaluating the cost-effectiveness of new targeted therapies in MCL.

This large Swedish real-world study on limited-stage MCL demonstrates that radiotherapy-containing frontline regimens are associated with excellent long-term outcomes, supporting a curative-intent, less-intensive approach for this rare subset.

An MCL patient post-autologous transplant developed persistent COVID-19 with a novel Remdesivir resistance mutation, highlighting the risk of immunocompromised hosts becoming reservoirs for drug-resistant SARS-CoV-2 variants.

This SEER database analysis confirms older age and advanced stage interact to worsen survival, while also identifying widowed marital status as an independent predictor of higher mortality in MCL.

This 20-year Taiwanese retrospective study confirms that frontline rituximab, intensive chemotherapy, and autologous transplant are associated with improved survival, validating these established strategies in a real-world Asian cohort.

This large retrospective study of 476 MCL patients aged ≥80 provides crucial real-world outcome data, informing treatment selection and expectations in the very elderly population.

This large, single-center retrospective study characterizes the aggressive nature and poor outcomes of MCL with cutaneous involvement, providing crucial real-world data for managing this rare presentation.

This large US prospective cohort study suggests outdoor air pollution is a potential environmental risk factor for developing specific hematologic cancer subtypes, highlighting the importance of subtype-specific etiological research.

This study defines the unique treatment patterns, clinical outcomes, and genomic landscape of Hepatitis B-associated MCL, providing crucial data for managing this complex patient subgroup.

Real-world registry data from Ukraine (2019-2021) reports a 3-year overall survival of 61% for newly diagnosed MCL patients, providing a crucial benchmark for outcomes in this region.

This narrative review of Malaysian B-cell lymphoma research identifies only three mantle cell lymphoma papers, highlighting a significant data gap and the need for more regional epidemiological studies.

This large SEER database study identifies being unmarried, particularly widowed, as an independent negative prognostic factor for survival in MCL, underscoring the need for enhanced psychosocial support.

Mendelian randomization analysis reveals that genetically longer telomeres are a causal risk factor for developing hematological malignancies, including MCL, suggesting a potential inherited predisposition for the disease.

This large retrospective study of orbital lymphomas identifies mantle cell lymphoma as a rare subtype but provides no specific clinical or prognostic data for this particular presentation.

A Mendelian randomization study provides causal evidence that genetically predicted longer telomere length increases the risk of developing MCL, suggesting a role for enhanced cellular proliferation in pathogenesis.

This real-world study shows significant MCL-related mortality after first relapse (23%), suggesting high-risk patients may not survive to receive novel therapies, supporting their use in earlier lines.

This 15-year real-world study benchmarks MCL survival outcomes, reflecting evolving treatment eras and providing crucial prognostic data from routine clinical practice.

This retrospective study outlines real-world treatment patterns for MCL from a single private practice in Brazil, providing crucial data on management outside of traditional clinical trial or academic settings.

This retrospective review of 14 Moroccan patients describes real-world MCL clinical features and treatment patterns, providing rare epidemiological data from North Africa.

This Mendelian randomization study suggests potential causal links between socioeconomic factors and lymphoma development, which may help define modifiable risk factors relevant to MCL etiology.

In a large retrospective series of bilateral lacrimal gland lesions, mantle cell lymphoma was identified as a rare cause (4.4%), highlighting an uncommon extranodal presentation for clinicians.

This case of lacrimal sac MCL, initially misdiagnosed as a mucocele, highlights a rare extranodal presentation requiring histopathological confirmation for accurate diagnosis in atypical periorbital masses.