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Michael Wang

Professor, Department of Lymphoma and Myeloma; Director, MCL Program of Excellence

MD Anderson Cancer Center · Houston, United States

About

Professor of Lymphoma/Myeloma at MD Anderson. One of the world's leading MCL investigators, pioneering combination strategies and novel targeted therapies. Has led numerous clinical trials for relapsed and frontline MCL.

Specialties
BTK inhibitorsClinical trialsNovel agentsRelapsed/refractory MCL
Key Trials
WINDOW-1WINDOW-2ZUMA-2SHINE
Publications (125)

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single-Cell Multi-Omics.

American journal of hematology · Apr 17, 2026

Clinical strategies for lymphoma management: Recommendations from the Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Consensus Conference 2025.

Cancer · Apr 15, 2026

Next-Generation Sequencing for Lymphoid Neoplasms: Real-World Utility from a Clinical Assay.

Human pathology · Apr 11, 2026

Correction: Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations.

Blood cancer journal · Apr 8, 2026

Mitochondrial ACSS1 Links Acetate Metabolism to Pyrimidine Biosynthesis in Nutrient-Stressed B-Cell Lymphomas.

Cancer letters · Apr 7, 2026

Targeting UHRF1 induces regression of aggressive mantle cell lymphoma.

Leukemia · Mar 24, 2026

Brexucabtagene autoleucel for BTKi-naive relapsed/refractory mantle cell lymphoma: primary analysis of ZUMA-2 cohort 3.

Blood · Mar 19, 2026

Phase 1 Trial of BCL-2 Inhibitor Lisaftoclax (APG-2575) in Chinese Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Other Non-Hodgkin Lymphomas.

Clinical lymphoma, myeloma & leukemia · Mar 17, 2026

Real-world comparative effectiveness of Bruton tyrosine kinase inhibitors in relapsed/refractory mantle cell lymphoma.

Blood advances · Mar 10, 2026

Family history of haematological malignancy and prognosis across non-Hodgkin lymphoma subtypes.

British journal of haematology · Mar 10, 2026

Inhibition of CDC20 suppresses the development and progression of mantle cell lymphoma through PI3K/AKT pathway.

Annals of hematology · Mar 9, 2026

Clinical characteristics and prognostic features of patients with blastoid and pleomorphic variant mantle cell lymphoma: a real-world study in China.

Annals of hematology · Mar 7, 2026

Efficacy and safety of zanubrutinib combined with age-adapted bendamustine and rituximab followed by zanubrutinib maintenance therapy in elderly patients with mantle cell lymphoma: a retrospective analysis.

Leukemia & lymphoma · Mar 7, 2026

Proteogenomic features define subtypes of mantle cell lymphoma.

Blood advances · Mar 5, 2026

Cell-free chromatin state tracing reveals disease origin and therapy responses.

Nature · Mar 4, 2026

Efficacy and Safety of Capivasertib (AZD5363), a Potent, Oral Pan-AKT Inhibitor, in Patients with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (CAPITAL).

Clinical cancer research : an official journal of the American Association for Cancer Research · Mar 2, 2026

Benefit of rituximab maintenance after first-line bendamustine-rituximab in patients with mantle cell lymphoma.

Blood advances · Feb 24, 2026

Correction: The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma.

Experimental hematology & oncology · Feb 11, 2026

Real-world characteristics, treatment patterns, and outcomes of patients with mantle cell lymphoma by line of therapy.

Future oncology (London, England) · Feb 1, 2026

TP53 mutation heterogeneity reveals distinct prognoses in mantle cell lymphoma.

Annals of hematology · Jan 21, 2026

A novel immune model predicts the prognosis of mantle cell lymphoma.

Frontiers in medicine · Jan 1, 2026

Overcoming Resistance and Relapse in CAR-T and CAR-NK Cell Therapies: From Bench to Bedside.

Research (Washington, D.C.) · Jan 1, 2026

May obesity increase the risk of lymphoma? Insights from genetic evidence.

Expert review of hematology · Jan 1, 2026

SOX11 modulates BCR signaling through the PAX5/CD19 axis for therapeutic targeting in BTK-resistant mantle cell lymphoma.

Blood advances · Dec 23, 2025

Mantle Cell Lymphoma Presenting as a Primary Cutaneous Mass: A Case Report.

Acta dermato-venereologica · Dec 7, 2025

Suspicious Laryngeal Mass: A Case Of Recurrent Mantle Cell Lymphoma.

Ear, nose, & throat journal · Dec 1, 2025

Clinical outcomes and therapeutic modalities in older Chinese patients with MCL: a multi-center real-world retrospective study.

Annals of medicine · Dec 1, 2025

Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study.

NPJ precision oncology · Nov 21, 2025

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma.

Blood · Nov 20, 2025

Treatment and outcomes of progression of disease post-CAR T-cell therapy in mantle cell lymphoma: a multicenter analysis.

Blood advances · Nov 11, 2025

Mantle cell lymphoma presenting primarily as cutaneous lesions: A case report.

World journal of clinical cases · Nov 6, 2025

Albumin nanocomplex of BCL-2/xL inhibitor reduced platelet toxicity and improved anticancer efficacy in myeloproliferative neoplasm and lymphoma.

Biomaterials · Nov 1, 2025

Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion.

Virchows Archiv : an international journal of pathology · Nov 1, 2025

Patient-derived organoid modeling predicts personalized drug responses in prostate-metastatic mantle cell lymphoma: a case report.

Anti-cancer drugs · Nov 1, 2025

Real-world outcomes of brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma: a CIBMTR analysis.

Blood advances · Oct 28, 2025

YX0798 is a highly potent, selective, and orally effective CDK9 inhibitor for treating aggressive lymphoma.

Blood advances · Oct 14, 2025

Outpatient Brexucabtagene Autoleucel in B-Cell Acute Lymphoblastic Leukemia and Mantle Cell Lymphoma.

American journal of hematology · Oct 1, 2025

Ibrutinib inhibits the replication of multiple poxviruses by targeting the Bruton tyrosine kinase.

Journal of virology · Sep 23, 2025

Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma.

Cell reports. Medicine · Sep 16, 2025

Transcriptional Analysis of Effusion-Based Lymphoma Supports a Post-Germinal Center Origin and Specific Inflammatory Signal Background.

Cancers · Sep 12, 2025

Acalabrutinib alleviates metabolic dysfunction-associated steatotic liver disease by regulating bile acid metabolism.

The international journal of biochemistry & cell biology · Aug 1, 2025

Nuclear Receptor-Binding SU(VAR)3-9, Enhancer of Zeste, Trithorax Domain Structural Domain Protein 2 Serves as a Potential Prognostic Biomarker in Mantle Cell Lymphoma.

Laboratory investigation; a journal of technical methods and pathology · Aug 1, 2025

CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis.

Phytomedicine : international journal of phytotherapy and phytopharmacology · Jul 25, 2025

Acalabrutinib Plus Bendamustine-Rituximab in Untreated Mantle Cell Lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · Jul 10, 2025

IGH/IGK gene rearrangement in the diagnosis of B-cell non-Hodgkin lymphoma: experience from three centers.

Annals of hematology · Jul 1, 2025

Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance.

Journal of advanced research · Jul 1, 2025

Prognostic biomarkers in MCL: insights from the SHINE trial on the impact of MCL35 score and TP53 mutation status.

Blood · Jun 19, 2025

Improvements in Outcomes in Older Patients With Mantle Cell Lymphoma Are Associated With Improvements Across Multiple Lines of Therapy.

Clinical lymphoma, myeloma & leukemia · Jun 1, 2025

Perspectives on Current Challenges and Emerging Approaches for Lymphoma Management From the First Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Conference.

Clinical lymphoma, myeloma & leukemia · Jun 1, 2025

CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma.

Nature communications · May 29, 2025

Genomic signatures in plasma circulating tumor DNA reveal treatment response and prognostic insights in mantel cell lymphoma.

Cancer cell international · May 3, 2025

SQSTM1/p62 predicts prognosis and upregulates the transcription of CCND1 to promote proliferation in mantle cell lymphoma.

Protoplasma · May 1, 2025

A novel research model of clonal evolution in mantle cell lymphoma at the single-cell genomic level.

Genes & diseases · May 1, 2025

Phase 2 trial of ibrutinib in previously untreated high-risk smoldering mantle cell lymphoma.

Leukemia & lymphoma · May 1, 2025

Optical genome mapping reveals diverse mechanisms of cyclin activation in mantle cell lymphomas lacking IGH::CCND1.

Human pathology · May 1, 2025

Mantle cell lymphoma with a prominent intrasinusoidal pattern of bone marrow involvement and circulating "prolymphocytoid" cells: an unusual pathological presentation posing diagnostic pitfalls.

Journal of hematopathology · Apr 15, 2025

[Composite diffuse large B-cell lymphoma and CD5-negative mantle cell lymphoma: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology · Apr 8, 2025

Small-molecule BTK inhibitors: From discovery to clinical application.

Bioorganic chemistry · Apr 1, 2025

Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma.

Annals of hematology · Apr 1, 2025

Impact of splenectomy on prognosis in lymphoma with splenic involvement.

European journal of medical research · Mar 28, 2025

Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.

The Journal of clinical investigation · Mar 17, 2025

POD24-Based prognostic signature enables personalized risk stratification in mantle cell lymphoma.

Scientific reports · Mar 13, 2025

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Cancer biology & medicine · Mar 12, 2025

Challenges of treating mantle cell lymphoma in older adults.

Leukemia & lymphoma · Mar 1, 2025

Safety and efficacy of acalabrutinib plus bendamustine and rituximab in patients with treatment-naïve or relapsed/refractory mantle cell lymphoma: phase Ib trial.

Haematologica · Mar 1, 2025

The optimal time and clinical implications of measurable residual disease detection in mantle cell lymphoma.

Annals of hematology · Mar 1, 2025

Causal Associations of Gut Microbiota Species With Lymphoma: A Two-Sample Mendelian Randomization Study.

Hematological oncology · Mar 1, 2025

Building a new score system for the diagnosis and differential diagnosis of typical CLL/SLL, atypical CLL/SLL, and MCL based on the flow cytometry immunophenotyping.

Annals of hematology · Mar 1, 2025

[Indolent leukemic non-nodal mantle cell lymphoma with TP53 mutation misdiagnosed as chronic lymphocytic leukemia: a case report and literature review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · Feb 14, 2025

High-risk MCL: recognition and treatment.

Blood · Feb 13, 2025

Ibrutinib plus venetoclax in relapsed or refractory mantle cell lymphoma (SYMPATICO): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.

The Lancet. Oncology · Feb 1, 2025

Development of a novel prognostic model for mantle cell lymphoma based on quantitative detection of CD3 by quantitative dot blot.

Frontiers in oncology · Jan 1, 2025

Efficacy and safety of tirabrutinib monotherapy in relapsed or refractory B-cell lymphomas/leukemia: a meta-analysis.

Frontiers in pharmacology · Jan 1, 2025

Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway.

Current molecular medicine · Jan 1, 2025

Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial.

Haematologica · Jan 1, 2025

Novel therapeutic agents and intensive chemotherapy improve survival outcomes in patients with mantle cell lymphoma.

American journal of cancer research · Jan 1, 2025

Navigating the changing landscape of BTK-targeted therapies for B cell lymphomas and chronic lymphocytic leukaemia.

Nature reviews. Clinical oncology · Dec 1, 2024

Clinical significance of Cyclin D1 by complete quantification detection in mantle cell lymphoma: positive indicator in prognosis.

Diagnostic pathology · Nov 21, 2024

Characteristics, treatment, and outcomes of mantle cell lymphoma with cutaneous involvement: a decade-long study at MD Anderson cancer center.

Leukemia & lymphoma · Nov 1, 2024

Unmet needs in relapsed/refractory mantle cell lymphoma (r/r MCL) post-covalent Bruton tyrosine kinase inhibitor (BTKi): a systematic literature review and meta-analysis.

Leukemia & lymphoma · Nov 1, 2024

Prognostic significance and biological implications of SM-like genes in mantle cell lymphoma.

Blood research · Oct 17, 2024

Author Correction: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma.

Nature communications · Oct 7, 2024

Simultaneous Determination of Ibrutinib, Dihydroxydiol Ibrutinib, and Zanubrutinib in Human Plasma by Liquid Chromatography-Mass Spectrometry/Mass Spectrometry.

Therapeutic drug monitoring · Oct 1, 2024

Evaluating pirtobrutinib for the treatment of relapsed or refractory mantle cell lymphoma.

Expert review of hematology · Oct 1, 2024

Ultrasound findings of non-Hodgkin's mantle cell lymphoma in the right inguinal region.

Medical ultrasonography · Sep 16, 2024

Acalabrutinib plus venetoclax and rituximab in treatment-naive mantle cell lymphoma: 2-year safety and efficacy analysis.

Blood advances · Sep 10, 2024

Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature.

Diagnostic pathology · Aug 24, 2024

PI3K inhibitor idelalisib enhances the anti-tumor effects of CDK4/6 inhibitor palbociclib via PLK1 in B-cell lymphoma.

Cancer letters · Aug 10, 2024

Identification of CD5/SOX11 double-negative pleomorphic mantle cell lymphoma.

Virchows Archiv : an international journal of pathology · Aug 1, 2024

Mantle cell lymphoma characterized by numerous diffuse polypoid lesions along the entire digestive tract: A case report.

Oncology letters · Aug 1, 2024

Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition.

Journal of translational medicine · Jul 4, 2024

Genetic and prognostic analysis of blastoid and pleomorphic mantle cell lymphoma: a multicenter analysis in China.

Annals of hematology · Jul 1, 2024

The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma.

Leukemia · Jul 1, 2024

The CDK9 inhibitor enitociclib overcomes resistance to BTK inhibition and CAR-T therapy in mantle cell lymphoma.

Biomarker research · Jun 18, 2024

[Clinicopathological features and prognosis analysis of bone marrow biopsy involvement in 95 cases with mantle cell lymphoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology · Jun 8, 2024

[Intestinal Mantle Cell Lymphoma Complicated With Ileocecal Intussusception in Adults:Report of One Case].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · Jun 1, 2024

Viral Hepatitis B Reactivation With Delayed Cholestatic Effect Secondary to Acalabrutinib.

ACG case reports journal · Jun 1, 2024

PRMT5 activates lipid metabolic reprogramming via MYC contributing to the growth and survival of mantle cell lymphoma.

Cancer letters · Jun 1, 2024

Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.

The Journal of clinical investigation · May 15, 2024

[Progressive necrotizing xanthogranuloma in both eyes: a case report].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · May 11, 2024

Efficacy and safety of brexucabtagene autoleucel CAR T-cell therapy with BTK inhibitors in the treatment of relapsed mantle cell lymphoma with central nervous system involvement.

Leukemia & lymphoma · May 1, 2024

Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus-associated mantle cell lymphoma.

Hematological oncology · May 1, 2024

Phase 1/2 multicenter trial of acalabrutinib in Chinese patients with relapsed/refractory mantle cell lymphoma.

Leukemia & lymphoma · May 1, 2024

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.

Blood advances · Apr 23, 2024

Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma.

Discover oncology · Apr 5, 2024

TP53 mutation is frequent in mantle cell lymphoma with EZH2 expression and have dismal outcome when both are present.

Human pathology · Apr 1, 2024

Lisocabtagene Maraleucel in Relapsed/Refractory Mantle Cell Lymphoma: Primary Analysis of the Mantle Cell Lymphoma Cohort From TRANSCEND NHL 001, a Phase I Multicenter Seamless Design Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · Apr 1, 2024

Clinical Warburg Effect in a Patient With Mantle Cell Lymphoma: A Case Report.

Cureus · Apr 1, 2024

The influence of marital status at diagnosis on survival of adult patients with mantle cell lymphoma.

Journal of cancer research and clinical oncology · Mar 11, 2024

Safety of bendamustine for the treatment of indolent non-Hodgkin lymphoma: a UK real-world experience.

Blood advances · Feb 27, 2024

Genetically predicted telomere length and the risk of 11 hematological diseases: a Mendelian randomization study.

Aging · Feb 22, 2024

The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma.

Experimental hematology & oncology · Feb 7, 2024

[Effect of Chlorambucil Combined with Ibrutinib on Mantle Cell Lymphoma Cell Line Jeko-1 and Its Related Mechanism].

Zhongguo shi yan xue ye xue za zhi · Feb 1, 2024

Mantle Cell Lymphoma Presenting as Erosive Duodenitis.

The American journal of gastroenterology · Feb 1, 2024

Novel BRAF N581S mutation in mantle cell lymphoma.

EJHaem · Feb 1, 2024

SOX11+ Large B-Cell Neoplasms: Cyclin D1-Negative Blastoid/Pleomorphic Mantle Cell Lymphoma or Large B-Cell Lymphoma?

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · Feb 1, 2024

FDA Approval Summary: Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research · Jan 5, 2024

Chimeric antigen receptor T-cell therapy in relapsed or refractory mantle cell lymphoma: a systematic review and meta-analysis.

Frontiers in immunology · Jan 1, 2024

Socioeconomic status, individual behaviors and risk for Lymphomas: a Mendelian randomization study.

Journal of Cancer · Jan 1, 2024

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma.

PloS one · Jan 1, 2024

Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors.

Haematologica · Jan 1, 2024

Ferroptosis-related prognostic model of mantle cell lymphoma.

Open medicine (Warsaw, Poland) · Jan 1, 2024

Matching-adjusted indirect comparison of acalabrutinib versus ibrutinib in relapsed/refractory mantle cell lymphoma.

Journal of medical economics · Jan 1, 2024

LINK-A: unveiling its functional role and clinical significance in human tumors.

Frontiers in cell and developmental biology · Jan 1, 2024

STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression.

Biologics : targets & therapy · Jan 1, 2024