MCL Clinical Trials
1230 trials from ClinicalTrials.gov. Recruiting trials shown first.
Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy
RECRUITINGNCT07003295·PHASE2·National Cancer Institute (NCI)·20 enrolled
Biospecimen CollectionComputed TomographyGlofitamabObinutuzumabPositron Emission Tomography
Pacritinib in Combination With a BTK Inhibitor for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma
RECRUITINGNCT06675123·PHASE1·City of Hope Medical Center·10 enrolled
BiopsyBiospecimen CollectionBone Marrow AspirationBone Marrow BiopsyBTK Inhibitor+3 more
Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
RECRUITINGNCT06859008·PHASE1·City of Hope Medical Center·37 enrolled
BiopsyBiospecimen CollectionBone Marrow AspirationBone Marrow BiopsyComputed Tomography+4 more
A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma
RECRUITINGNCT07377578·PHASE3·Guangzhou Lupeng Pharmaceutical Company LTD.·394 enrolled
RocbrutinibIbrutinibAcalabrutinibZanubrutinibOrelabrutinib
This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma
RECRUITINGNCT07121946·PHASE1·LTZ Therapeutics, Inc.·42 enrolled
LTZ-301LTZ-301LTZ-301
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
RECRUITINGNCT07285044·PHASE2·Mayo Clinic·27 enrolled
Cancer Therapeutic ProcedureCancer Therapeutic ProcedureQuestionnaire Administration
Pemigatinib in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas
RECRUITINGNCT06300528·PHASE2·University of Utah·27 enrolled
Pemigatinib
Clinical Trial to Evaluate the Efficacy and Safety of Pirtobrutinib With Rituximab in Patients With Mantle Cell Lymphoma
RECRUITINGNCT07285590·PHASE2·Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea·50 enrolled
Pirtobrutinib and rituximab
Relmacabtagene Autoleucel Combined With Sintilimab for Relapsed/Refractory B-cell Lymphoma
RECRUITINGNCT07077512·PHASE2·Sun Yat-sen University·30 enrolled
Autoleucel (Relmacabtagene Autoleucel)Sintilimab (PD-1 inhibitor)
Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With High-Risk Disease
RECRUITINGNCT07272499·PHASE2·Ruijin Hospital·25 enrolled
OrelabrutinibRituximab (R)Lisaftoclax (APG-2575)Lisaftoclax (APG-2575)
A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for Previously Untreated Mantle Cell Lymphoma in Spain
RECRUITINGNCT07029737·PHASE2·AstraZeneca·55 enrolled
Acalabrutinib + R-CHOP standard of careAcalabrutinib combination with RituximabAcalabrutinib monotherapy
A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06)
RECRUITINGNCT07082686·PHASE2·Beijing InnoCare Pharma Tech Co., Ltd.·68 enrolled
ICP-248
Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma
RECRUITINGNCT07460362·PHASE2·Peking University Third Hospital·43 enrolled
GlofitamabLenalidomide
Pomalidomide Plus Orelabrutinib and Zuberitamab in Untreated Mantle Cell Lymphoma
RECRUITINGNCT07257510·NA·Peking University Third Hospital·34 enrolled
PomalidomideOrelabrutinibZuberitamabZuberitamab
Orelabrutinib and Rituximab With Optional Autologous Hematopoietic Stem Cell Transplantation in MCL Treatment
RECRUITINGNCT07199296·PHASE2·Ruijin Hospital·45 enrolled
OrelabrutinibRituximab (R)BEAM (carmustine (BCNU), etoposide, cytarabine, melphalan)orelabrutinib maintenance
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
RECRUITINGNCT06839053·PHASE2·Fred Hutchinson Cancer Center·20 enrolled
Biospecimen CollectionBone Marrow BiopsyComputed TomographyGastrointestinal EndoscopyRituximab+2 more
Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
RECRUITINGNCT06533579·PHASE1 / PHASE2·Vironexis Biotherapeutics Inc.·32 enrolled
Dose Level 1, VNX-101Dose Level 2, VNX-101Dose Level 3, VNX-101Dose Level 4, VNX-101
Glofitamab Plus Ibrutinib With Obinutuzumab for the Treatment of Patients With Mantle Cell Lymphoma, IGNITE MCL Trial
RECRUITINGNCT06357676·PHASE1 / PHASE2·OHSU Knight Cancer Institute·27 enrolled
Biospecimen CollectionBone Marrow BiopsyComputed TomographyEchocardiographyFDG-Positron Emission Tomography+4 more
BRAZAN: A Randomized Phase 2 Study of Bendamustine, Rituximab, Cytarabine (AraC) Induction With Zanubrutinib (BRAZAN) Followed by Zanubrutinib/Rituximab +/- Sonrotoclax Maintenance in Treatment-Naïve Mantle Cell Lymphoma
RECRUITINGNCT06854003·PHASE2·Christine Ryan·60 enrolled
BendamustineRituximabCytarabineZanubrutinibSonrotoclax
Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk Younger Untreated Mantle Cell Lymphoma
RECRUITINGNCT06846489·PHASE2·Sun Yat-sen University·50 enrolled
AcalabrutinibRituximab
Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment
RECRUITINGNCT06784167·OHSU Knight Cancer Institute·45 enrolled
Non-Interventional Study
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
RECRUITINGNCT06742996·PHASE3·BeOne Medicines·300 enrolled
SonrotoclaxZanubrutinibPlacebo
Phase II Study of Glofitamab With Venetoclax +/- Zanubrutinib in High-risk Mantle-cell Lymphoma
RECRUITINGNCT06558604·PHASE2·The Lymphoma Academic Research Organisation·100 enrolled
ObinutuzumabGlofitamabVenetoclax Oral ProductZanubrutinib Oral Capsule
LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies
RECRUITINGNCT05990465·PHASE1·Medical College of Wisconsin·12 enrolled
PirtobrutinibLV20.19 CAR T cells
A Study of Patients With Relapsed/Refractory Mantle Cell Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting
RECRUITINGNCT06788652·Juno Therapeutics, Inc., a Bristol-Myers Squibb Company·300 enrolled
Lisocabtagene maraleucel
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
RECRUITINGNCT06564038·PHASE1 / PHASE2·AstraZeneca·408 enrolled
SurovatamigPrednisone (or equivalent)RituximabCyclophosphamideVincristine+2 more
Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma
RECRUITINGNCT06572618·PHASE2·City of Hope Medical Center·27 enrolled
Biospecimen CollectionBone Marrow BiopsyNemtabrutinibPositron Emission Tomography and Computed Tomography ScanRituximab
Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma
RECRUITINGNCT06667687·PHASE1·AbbVie·165 enrolled
ABBV-291
CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies
RECRUITINGNCT06208735·PHASE1·British Columbia Cancer Agency·24 enrolled
CLIC-2201
CD70-targeted immunoPET Imaging of Malignant Cancers
RECRUITINGNCT06852638·NA·RenJi Hospital·300 enrolled
[18F]F-RESCA-RCCB6[18F]F-RESCA-R8B4[18F]F-RESCA-RD06[68Ga]Ga-NOTA-R8B4[68Ga]Ga-NOTA-RD06+3 more
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