MCL Clinical Trials
1230 trials from ClinicalTrials.gov. Recruiting trials shown first.
The Study of Bendamustine, Rituximab, Ibrutinib, and Venetoclax in Relapsed, Refractory Mantle Cell Lymphoma
COMPLETEDNCT03295240·EARLY_PHASE1·Memorial Sloan Kettering Cancer Center·10 enrolled
BR-I (bendamustine, rituximab, ibrutinib)VEN (Venetoclax)
Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation
TERMINATEDNCT03246906·PHASE2·Fred Hutchinson Cancer Center·150 enrolled
Allogeneic Hematopoietic Stem Cell TransplantationCyclophosphamideCyclosporineMycophenolate MofetilSirolimus
Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma
COMPLETEDNCT03035331·PHASE1 / PHASE2·Mayo Clinic·11 enrolled
CryosurgeryDendritic Cell TherapyLaboratory Biomarker AnalysisPembrolizumabPneumococcal 13-valent Conjugate Vaccine+1 more
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22
UNKNOWNNCT03185494·PHASE1 / PHASE2·Chinese PLA General Hospital·30 enrolled
anti-CD19/22-CAR vector-transduced T cells
Blood Immunophenotyping in Staging of Indolent B-cell Lymphomas V1.0
UNKNOWNNCT03265158·Royal Marsden NHS Foundation Trust·108 enrolled
Entospletinib and Obinutuzumab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Non-Hodgkin Lymphoma
COMPLETEDNCT03010358·PHASE1 / PHASE2·Alexey Danilov, MD·24 enrolled
EntospletinibLaboratory Biomarker AnalysisObinutuzumabPharmacological Study
First-in-human Study of ATR Inhibitor BAY1895344 in Patients With Advanced Solid Tumors and Lymphomas
COMPLETEDNCT03188965·PHASE1·Bayer·229 enrolled
Elimusertib (BAY1895344)
Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (MCL)
COMPLETEDNCT03112174·PHASE3·Pharmacyclics LLC.·366 enrolled
IbrutinibVenetoclaxPlacebo Oral tablet to match Venetoclax
High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant
COMPLETEDNCT03128359·PHASE2·City of Hope Medical Center·38 enrolled
BusulfanCyclophosphamideFludarabine PhosphateHematopoietic Cell TransplantationLaboratory Biomarker Analysis+6 more
Phase I/Ib Study of Nivolumab & Veliparib in Patients With Advanced Solid Tumors & Lymphoma
COMPLETEDNCT03061188·PHASE1·Northwestern University·15 enrolled
Laboratory Biomarker AnalysisNivolumabPharmacological StudyVeliparib
UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep
COMPLETEDNCT02722668·PHASE2·Masonic Cancer Center, University of Minnesota·15 enrolled
FludarabineCyclophosphamideMMFSirolimusTBI+2 more
Vincristine Sulfate Liposome Injection (Marqibo®), Bendamustine and Rituximab-Phase I Trial in Indolent B-cell Lymphoma
COMPLETEDNCT02257242·PHASE1·Brown University·11 enrolled
RituximabBendamustineVincristine sulfate liposome injection
Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers
TERMINATEDNCT03037645·PHASE1 / PHASE2·Sunesis Pharmaceuticals·39 enrolled
SNS-062
Study of Bortezomib (BTZ) Treatment on Mantle Cell Lymphoma (MCL) in Chinese Participants
COMPLETEDNCT03053024·Xian-Janssen Pharmaceutical Ltd.·54 enrolled
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
COMPLETEDNCT03097770·PHASE1 / PHASE2·Chinese PLA General Hospital·100 enrolled
anti-CD19/20-CAR vector-transduced T cells
Study of Safety,Efficacy and Pharmacokinetics of CT-1530 in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia
UNKNOWNNCT02981745·PHASE1 / PHASE2·Centaurus Biopharma Co., Ltd.·200 enrolled
CT-1530
Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients
COMPLETEDNCT03028103·PHASE1·Epizyme, Inc.·32 enrolled
TazemetostatFluconazoleOmeprazoleRepaglinide
Allo HSCT Using RIC for Hematological Diseases
COMPLETEDNCT02661035·PHASE2·Masonic Cancer Center, University of Minnesota·156 enrolled
AllopurinolFludarabineCyclophosphamideATGTBI+4 more
Study to Evaluate Efficacy and Safety of BGB-3111 in Participants With Relapsed or Refractory Mantle Cell Lymphoma (MCL)
COMPLETEDNCT03206970·PHASE2·BeiGene·86 enrolled
Zanubrutinib
A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma
TERMINATEDNCT02978235·PHASE1·Taiho Oncology, Inc.·11 enrolled
TAS4464
Adoptive TReg Cell for Suppression of aGVHD After UCB HSCT for Heme Malignancies
TERMINATEDNCT02991898·PHASE2·Masonic Cancer Center, University of Minnesota·3 enrolled
Infusion of Treg
Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies
TERMINATEDNCT02483000·PHASE1·Fred Hutchinson Cancer Center·3 enrolled
Anti-CD20 B9E9 scFv-Streptavidin Fusion ProteinAutologous Hematopoietic Stem Cell TransplantationCarmustineClearing AgentCytarabine+7 more
Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haplo-HCT
COMPLETEDNCT02988466·PHASE2·Masonic Cancer Center, University of Minnesota·78 enrolled
Haplo HCT <55 years oldHaplo HCT ≥55 years oldGVHD ProphylaxisHaplo HCT ≥55 and < 65 years oldHaplo HCT ≥65 and ≤75 years old
Pembrolizumab and Ibrutinib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
COMPLETEDNCT02950220·PHASE1·Kami Maddocks·2 enrolled
IbrutinibLaboratory Biomarker AnalysisPembrolizumab
Study of IV CBL0137 in Previously Treated Hematological Subjects
TERMINATEDNCT02931110·PHASE1·Incuron·5 enrolled
CBL0137
The Efficacy and Safety of Bortezomib Combined With Fludarabine and Cytarabine Treatment for Mantle Cell Lymphoma
UNKNOWNNCT03016988·PHASE2·Tingbo Liu·50 enrolled
BortezomibFludarabineCytarabine
Peptide Receptor Radionuclide Therapy With 90Y-Dotatoc in Relapsed/Refractory Diffuse Large B Cell and Mantle Cell Lymphomas
TERMINATEDNCT02488512·PHASE2·Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS·1 enrolled
90Y-DOTATOC
Haploidentical BMT With Post-Transplant Cyclophosphamide and Bendamustine
COMPLETEDNCT02996773·PHASE1·University of Arizona·50 enrolled
BendamustineCyclophosphamide
Efficacy of Upfront and Maintenance Obinutuzumab in Mantle Cell Lymphoma Treated by DHAP and MRD Driven Maintenance
COMPLETEDNCT02896582·PHASE2·The Lymphoma Academic Research Organisation·86 enrolled
ObinutuzumabDexamethasoneAracytineCisplatinumEtoposide+2 more
Lenalidomide and Blinatumomab for the Treatment of Relapsed Non-Hodgkin Lymphoma
COMPLETEDNCT02568553·PHASE1·National Cancer Institute (NCI)·35 enrolled
BlinatumomabLenalidomide