t(11;14)

MCL Clinical Trials

1230 trials from ClinicalTrials.gov. Recruiting trials shown first.

Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
RECRUITING
NCT06054776·PHASE2·City of Hope Medical Center·40 enrolled
AcalabrutinibBiospecimen CollectionBone Marrow BiopsyComputed TomographyEchocardiography+4 more
SynKIR-310 for Relapsed/Refractory B-NHL
RECRUITING
NCT06544265·PHASE1·Verismo Therapeutics·36 enrolled
SynKIR-310
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
RECRUITING
NCT06542250·PHASE1 / PHASE2·AstraZeneca·174 enrolled
AZD5492
Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCL
RECRUITING
NCT06553872·PHASE2·H. Lee Moffitt Cancer Center and Research Institute·60 enrolled
PirtobrutinibBrexucabtagene Autoleucel
Obinutuzumab, Zanubrutinib, and Lenalidomide Followed Short-Cycle of Obinutuzumab and Cytarabine in Newly Diagnosed Mantle Cell Lymphoma
RECRUITING
NCT06504199·PHASE2·Institute of Hematology & Blood Diseases Hospital, China·39 enrolled
ObinutuzumabZanubrutinibLenalidomideCytarabineCAR-T
Bendamustine and Rituximab With or Without Orelabrutinib in MCL Treatment
RECRUITING
NCT06496308·PHASE3·Ruijin Hospital·78 enrolled
OrelabrutinibBendamustineRituximabVenetoclax
Sequential Treatment of CD19 CARNK and 7x19 CAR-T in R/R B Cell Lymphoma
RECRUITING
NCT06464861·PHASE1·Second Affiliated Hospital, School of Medicine, Zhejiang University·52 enrolled
CD19-CAR-NK/T
Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma
RECRUITING
NCT06252675·PHASE2·University of California, San Francisco·30 enrolled
ObinutuzumabGlofitamabPirtobrutinibTumor ImagingBiospecimen Collection+2 more
Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) Patients
RECRUITING
NCT06263491·PHASE2·M.D. Anderson Cancer Center·50 enrolled
RituximabPirtobrutinib
A Global Phase 3 Study of Orelabrutinib+BR Vs.BR in Pts with TN MCL
RECRUITING
NCT06363994·PHASE3·InnoCare Pharma Inc.·476 enrolled
OrelabrutinibBendamustine InjectionRituximabOrelabrutinib Placebo
A Multicenter, Prospective, Phase II Study of Zanubrutinib for Maintenance in Patients With Mantle Cell Lymphoma
RECRUITING
NCT06341556·PHASE2·Fudan University·52 enrolled
Zanubrutinib
Zanubrutinib Plus Rituximab for Patients With Indolent Mantle Cell Lymphoma
RECRUITING
NCT05635162·PHASE2·University College, London·50 enrolled
ZanubrutinibRituximab
Zanubrutinib and Tafasitamab in Mantle Cell Lymphoma
RECRUITING
NCT06029309·PHASE1 / PHASE2·Alvaro Alencar, MD·27 enrolled
ZanubrutinibTafasitamab
AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas
RECRUITING
NCT06340737·PHASE1·Stanford University·148 enrolled
CD22CART Infusion
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
RECRUITING
NCT06191887·PHASE1·Mayo Clinic·27 enrolled
Autologous BAFFR-targeting CAR T CellsBendamustineBiopsyBiospecimen CollectionBone Marrow Aspiration and Biopsy+7 more
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
RECRUITING
NCT05887167·PHASE1·Joshua Sasine, MD, PhD·20 enrolled
autologous hematopoietic stem cells added to planned CAR T
CAR-T-cell Treatment for Untreated High Risk MANtle Cell Lymphoma
RECRUITING
NCT06482684·PHASE2·Christian Schmidt, MD·150 enrolled
KTE-X19Ibrutinib
A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies
RECRUITING
NCT06045910·PHASE1 / PHASE2·Cancer Research UK·84 enrolled
ALETA-001
Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study
RECRUITING
NCT06151730·Mayo Clinic·100 enrolled
Non-Interventional Study
Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
RECRUITING
NCT05910801·PHASE2·Academic and Community Cancer Research United·100 enrolled
BiopsyBiospecimen CollectionBone Marrow AspirationBone Marrow BiopsyComputed Tomography+6 more
Efficacy of Polatuzumab, Bendamustine and Rituximab in Patients With Relapsed/ Refractory Mantle Cell Lymphoma
RECRUITING
NCT05868395·PHASE2·Medical University of Vienna·16 enrolled
Polatuzumab, bendamustin und rituximab
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
RECRUITING
NCT05004064·PHASE2·University College, London·48 enrolled
AcalabrutinibRituximab
A Study of the Zanubrutinib Given in Combination With Bendamustine and Rituximab in (Elderly or TP53 Alterations or Chemotherapy Intolerance) Patients With Newly Diagnosed Mantle Cell Lymphoma
RECRUITING
NCT06136351·PHASE2·Ruijin Hospital·23 enrolled
ZanubrutinibRituximabBendamustin
CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma
RECRUITING
NCT06026319·PHASE1·Marcela V. Maus, M.D.,Ph.D.·24 enrolled
CD79b-19 CAR T cellsCyclophosphamideFludarabine
A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
RECRUITING
NCT06084936·PHASE3·Hoffmann-La Roche·182 enrolled
ObinutuzumabGlofitamabRituximabBendamustineLenalidomide+1 more
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
RECRUITING
NCT05976763·PHASE3·Alliance for Clinical Trials in Oncology·421 enrolled
ZanubrutinibRituximabPatient ObservationBone Marrow BiopsyFludeoxyglucose F-18+7 more
A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
RECRUITING
NCT06022029·PHASE1·OncoNano Medicine, Inc.·168 enrolled
ONM-501Cemiplimab
A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure.
RECRUITING
NCT05833763·PHASE2·Australasian Leukaemia and Lymphoma Group·42 enrolled
GlofitamabPirtobrutinibObinutuzumabTocilizumab
A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas
RECRUITING
NCT05934838·PHASE1·Weill Medical College of Cornell University·15 enrolled
Tazemetostat Pill
Registry Platform Hematologic Malignancies (RUBIN) - Extension of Tumor Registry Lymphatic Neoplasms
RECRUITING
NCT06043011·iOMEDICO AG·2950 enrolled
Routine care as per site standard.