t(11;14)
← All Drugs

Rituximab

Rituxan / MabThera · Anti-CD20 antibody · CD20

Mechanism

Chimeric monoclonal antibody targeting CD20 on B cells. Backbone of all MCL immunochemotherapy regimens and maintenance therapy.

Indication in MCL

Backbone of frontline and maintenance therapy in MCL

Approval Status
FDAApproved (1997-11)NHL (including MCL)
Key Trials
LYMATRIANGLESHINENordic MCL2
Related Papers (20)

Outcomes of transplant-eligible and transplant-ineligible patients with mantle cell lymphoma in Ontario.

Blood neoplasia · May 2026

Unusual Skeletal Muscle Recurrence of Mantle Cell Lymphoma After Rituximab Maintenance Therapy Detected on 18 F-FDG PET/CT.

Clinical nuclear medicine · May 2026

Zanubrutinib-rituximab followed by shortened chemoimmunotherapy as frontline treatment for mantle cell lymphoma (CHESS): a phase II trial.

Nature communications · Mar 2026

Epidemiology, treatment patterns, and survival outcomes of patients with mantle cell lymphoma in Germany: a retrospective analysis of administrative claims data.

Annals of hematology · Mar 2026

Efficacy and safety of zanubrutinib combined with age-adapted bendamustine and rituximab followed by zanubrutinib maintenance therapy in elderly patients with mantle cell lymphoma: a retrospective analysis.

Leukemia & lymphoma · Mar 2026

CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: An Unusual Presentation.

The American Journal of dermatopathology · Mar 2026

Diffuse Gastrointestinal Polyposis Revealing Mantle Cell Lymphoma: A Case Highlighting a Diagnostic Pitfall.

Cureus · Mar 2026

MRD-driven initial therapy of acalabrutinib and lenalidomide plus rituximab or obinutuzumab for mantle cell lymphoma.

Blood advances · Feb 2026

Benefit of rituximab maintenance after first-line bendamustine-rituximab in patients with mantle cell lymphoma.

Blood advances · Feb 2026

IMPACT OF RITUXIMAB MAINTENANCE ON SURVIVAL IN PATIENTS WITH MANTLE CELL LYMPHOMA; A POPULATION-BASED COHORT STUDY.

Blood advances · Feb 2026

[Acalabrutinib plus bendamustine and rituximab for older patients with untreated mantle cell lymphoma].

Bulletin du cancer · Feb 2026

Real-world characteristics, treatment patterns, and outcomes of patients with mantle cell lymphoma by line of therapy.

Future oncology (London, England) · Feb 2026

[Clinical Analysis of Autologous Hematopoietic Stem Cell Transplantation in Treatment of Mantle Cell Lymphoma: a Multicenter Retrospective Study].

Zhongguo shi yan xue ye xue za zhi · Feb 2026

Outcome of patients with mantle cell lymphoma after failure of anti-CD19 CAR T-cell therapy: a DESCAR-T study by LYSA Group.

Blood advances · Jan 2026

Mantle Cell Lymphoma Mimicking Parotid Neoplasm: A Rare Case Report.

Iranian journal of otorhinolaryngology · Jan 2026

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation.

Nature cell biology · Jan 2026

Noninvasive genotyping and early disease dynamics demonstrate the efficacy of ibrutinib in combination with immunochemotherapy in patients with mantle cell lymphoma treated in the TRIANGLE trial.

Leukemia · Jan 2026

Bruton Tyrosine Kinase Inhibitors in Mantle Cell Lymphoma: What Are the Current Options?

European journal of haematology · Dec 2025

Chronic meningoencephalitis due to enterovirus A71 complicating rituximab therapy.

Revue neurologique · Dec 2025

Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma.

Nature communications · Nov 2025