t(11;14)
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Brexucabtagene autoleucel

Tecartus · CAR-T · CD19

Mechanism

Anti-CD19 CAR T-cell therapy. Autologous T cells genetically engineered to express a chimeric antigen receptor targeting CD19.

Indication in MCL

Relapsed/refractory MCL after BTK inhibitor therapy

Approval Status
FDAApproved (2020-07)R/R MCL
EMAApproved (2020-12)R/R MCL
Key Trials
ZUMA-2
Related Papers (20)

Bridging practices prior to brexucabtagene autoleucel for mantle cell lymphoma in the United Kingdom: An analysis of modality, response, toxicity and survival.

British journal of haematology · Apr 2026

Brexucabtagene autoleucel for BTKi-naive relapsed/refractory mantle cell lymphoma: primary analysis of ZUMA-2 cohort 3.

Blood · Mar 2026

OUTCOMES OF PATIENTS OVER 70 YEARS TREATED WITH BREXU-CEL FOR R/R MANTLE CELL LYMPHOMA: A STUDY FROM THE CTIWP OF EBMT.

Blood advances · Mar 2026

Ibrutinib exposure correlates with improved efficacy of CAR T cells in patients with mantle cell lymphoma.

Blood advances · Feb 2026

Chimeric antigen receptor T-cell therapy and immune effector cell-associated neurotoxicity syndrome: A meta-analysis.

Critical reviews in oncology/hematology · Feb 2026

Outcome of patients with mantle cell lymphoma after failure of anti-CD19 CAR T-cell therapy: a DESCAR-T study by LYSA Group.

Blood advances · Jan 2026

Managing Treatment-Emergent Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome Following CAR-T Cell Therapy: A Case-Based Review of the use of Emapalumab.

Hematological oncology · Jan 2026

Case Report: Durable remission of intraocular mantle cell lymphoma after CD19 CAR-T therapy.

Frontiers in immunology · Jan 2026

Real-world outcomes of brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma: a CIBMTR analysis.

Blood advances · Oct 2025

Outpatient Brexucabtagene Autoleucel in B-Cell Acute Lymphoblastic Leukemia and Mantle Cell Lymphoma.

American journal of hematology · Oct 2025

Brexucabtagene Autoleucel versus Allogeneic Hematopoietic Cell Transplantation in Relapsed and Refractory Mantle Cell Lymphoma.

Blood cancer discovery · May 2025

[Efficacy and toxicity of brexucabtagene autoleucel in the treatment of high-risk mantle cell lymphoma: description of a clinical case].

Recenti progressi in medicina · Mar 2025

Brexucabtagene autoleucel in-vivo expansion and BTKi refractoriness have a negative influence on progression-free survival in mantle cell lymphoma: Results from CART-SIE study.

British journal of haematology · Feb 2025

Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, followed by an intestinal perforation: a case report.

Journal of medical case reports · Jan 2025

Late-onset relapsing neurotoxicity after Brexucabtagene autoleucel associated with high chimeric antigen receptor T cells in cerebrospinal fluid.

Cytotherapy · Jan 2025

Brexucabtagene autoleucel in relapsed or refractory mantle cell lymphoma, intention-to-treat use in the DESCAR-T registry.

Haematologica · Nov 2024

Unmet needs in relapsed/refractory mantle cell lymphoma (r/r MCL) post-covalent Bruton tyrosine kinase inhibitor (BTKi): a systematic literature review and meta-analysis.

Leukemia & lymphoma · Nov 2024

Bendamustine as Lymphodepletion for Brexucabtagene Autoleucel Therapy of Mantle Cell Lymphoma.

Transplantation and cellular therapy · Jul 2024

CAR19 monitoring by peripheral blood immunophenotyping reveals histology-specific expansion and toxicity.

Blood advances · Jun 2024

Brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma in the United Kingdom: A real-world intention-to-treat analysis.

HemaSphere · Jun 2024