MCL Literature Feed

This case series on a rare kidney disease (ABBA) reports a paraneoplastic association with mantle cell lymphoma, highlighting a rare non-hematologic manifestation potentially responsive to B-cell directed therapy.

This review synthesizes current knowledge on MCL genetic markers, advocating for a personalized medicine approach that integrates molecular profiles like TP53 to improve risk stratification and guide therapy.

This preclinical study identifies a novel cyclin D1 degradation pathway via SUMOylation, showing its disruption causes an MCL-like phenotype and that arsenic trioxide can therapeutically enhance this process.

In a retrospective analysis of 95 MCL cases, specific histopathological patterns of bone marrow involvement were identified as key prognostic indicators, aiding in initial patient risk stratification.

This case series characterizes the immunohistochemical and molecular genetic profile of rare lacrimal gland MCL, providing crucial diagnostic insights for this uncommon extranodal presentation.

An 85-year-old MCL patient on ibrutinib developed a cutaneous EBV+ NK/T-cell lymphoma that resolved spontaneously, highlighting a rare, potentially indolent lymphoproliferative disorder in this treatment setting.

A rare case of primary adrenal mantle cell lymphoma presenting as a retroperitoneal mass mimicking paraganglioma highlights the critical need for histological diagnosis of atypical adrenal tumors.

A steroid-sparing regimen of doxycycline, cetirizine, and valacyclovir successfully managed exaggerated mosquito bite reactions in an indolent MCL patient, offering a novel approach for this rare cutaneous manifestation.

This case report describes a rare presentation of intestinal MCL causing ileocecal intussusception in an adult, highlighting a critical differential diagnosis for this acute abdominal condition requiring pathological confirmation.

This case report describes a rare presentation of primary MCL causing life-threatening laryngotracheal stenosis, highlighting the need to consider lymphoma in the differential diagnosis of acute airway obstruction.

This case report links MCL with Henoch-Schönlein purpura and IgA-nephritis, highlighting a rare paraneoplastic syndrome with specific dermatological and renal manifestations for clinicians to recognize.

This report describes two contrasting presentations of MCL with plasmacytic differentiation, highlighting the diagnostic challenge of this rare variant which can mimic plasma cell neoplasms, impacting management.

This case report describes the rare phenomenon of biclonal mantle cell lymphoma, highlighting clonal heterogeneity and evolution which can impact diagnosis, disease progression, and therapeutic resistance.

Gene expression profiling identifies two distinct molecular MCL subtypes, C1 and C2, with C2 showing high proliferation and poor prognosis, providing a powerful new biomarker for risk stratification.

This case links progressive necrotizing xanthogranuloma, a rare paraneoplastic syndrome, as the presenting sign of MCL, underscoring the need for hematologic workup for specific skin/ocular findings.

This case report describes mantle cell lymphoma presenting as multiple colonic polyposis causing obstruction, highlighting a rare gastrointestinal manifestation requiring specific immunohistochemical diagnosis for confirmation.

This case report describes indolent mantle cell lymphoma presenting with significant renal disease, highlighting a rare extranodal manifestation as the primary cause of organ dysfunction.

A rare, non-nodal MCL case with hairy cell-like features and a TP53 mutation showed an indolent course, challenging prognostic assumptions and emphasizing comprehensive genomic and pathologic evaluation.

MNDA is highly expressed in nearly 80% of mantle cell lymphoma cases, but its utility in distinguishing MCL from marginal zone lymphoma is limited due to overlapping expression.

This case report describes a rare presentation of primary, localized orbital mantle cell lymphoma successfully managed with local excision and radiotherapy, highlighting an unusual clinical scenario for this systemic disease.

This case report highlights unprovoked venous thromboembolism as a presenting symptom of mantle cell lymphoma, underscoring the need for a prompt malignancy workup in such clinical scenarios.

This narrative review of Malaysian B-cell lymphoma research identifies only three mantle cell lymphoma papers, highlighting a significant data gap and the need for more regional epidemiological studies.

This case report describes the rare Warburg effect (severe hypoglycemia, lactic acidosis) in an MCL patient, highlighting its potential for cardiac toxicity and the utility of hemodialysis for stabilization.

MCL with concurrent EZH2 expression and TP53 mutation is frequent and identifies a patient subgroup with a dismal outcome, establishing a powerful negative prognostic biomarker combination.

This review summarizes fundamental MCL characteristics, including the t(11;14) translocation and key high-risk features (high Ki67, blastoid variant, TP53 mutation) essential for patient risk stratification.

This paper does not study MCL but finds high Notch1 protein expression in methotrexate-associated DLBCL, suggesting a pathogenic role for this pathway, which is also altered in MCL.

Large B-cell lymphoma with IRF4 rearrangement can mimic blastoid MCL by presenting in older adults and expressing CD5, but negativity for Cyclin D1 and SOX11 is crucial for differential diagnosis.

This large retrospective study of orbital lymphomas identifies mantle cell lymphoma as a rare subtype but provides no specific clinical or prognostic data for this particular presentation.

Palliative radiotherapy provided profound tumor reduction for an elderly patient with blastoid MCL presenting as a rare oropharyngeal mass, demonstrating a personalized, less-intensive frontline treatment option.

An AI model using ensemble convolutional neural networks distinguished MCL from CLL and FL on pathology images with 99% accuracy, offering a potential tool for automated histopathological diagnosis.