MCL Clinical Trials
1230 trials from ClinicalTrials.gov. Recruiting trials shown first.
This Clinical Trial is a Single-arm, Non-randomized Pilot Trial to Determine the Safety of Administering Autologous Anti-C19 Cells (ARI-0001) and the Feasibility of Local CAR-T Cell Production in Patients Over 18 Years of Age With Relapsed/Refractory (R/R) CD19+ Hematologic Malignancies, Including R
NOT YET RECRUITINGNCT07412405·NA·GUSTAVO SALGUERO·12 enrolled
ARI-0001 T cells with anti-CD19 chimeric antigen receptor (CAR-T)
Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma
NOT YET RECRUITINGNCT07444710·PHASE1·National Cancer Institute (NCI)·16 enrolled
Biospecimen CollectionCisplatinComputed TomographyCyclophosphamideCytarabine+7 more
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event
NOT YET RECRUITINGNCT07499128·NA·National Cancer Institute (NCI)·136 enrolled
TempTraqVitalTraq
Study With Glofitamab in Patients With MCL and Inadequate Response or Relapse Following CAR T-cell Therapy
NOT YET RECRUITINGNCT07453095·PHASE2·Fondazione Italiana Linfomi - ETS·41 enrolled
Glofitamab
Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell Therapy
NOT YET RECRUITINGNCT07341191·PHASE2·Canadian Cancer Trials Group·40 enrolled
ZanubrutinibSonrotoclaxCAR-T Cell Therapy
A Study to Evaluate MTM-H-001 Injection in Adult Participants With Relapsed or Refractory B-cell Malignancies
NOT YET RECRUITINGNCT07476378·NA·Cancer Institute and Hospital, Chinese Academy of Medical Sciences·69 enrolled
MTM-H-001 Injection
A Study of APG-3288 in Relapsed/Refractory Blood Cancers
NOT YET RECRUITINGNCT07424833·PHASE1·Ascentage Pharma Group Inc.·180 enrolled
APG-3288
PirtobrUtinib as Frontline Therapy for Elderly Unfit/Frail Patient With MAntle Cell Lymphoma
NOT YET RECRUITINGNCT07207785·PHASE2·Fondazione Italiana Linfomi - ETS·56 enrolled
Pirtobrutinib
ZSDT for the Treatment of R/R Mantle Cell Lymphoma After BTK Inhibitor Failure: a Multi-center Prospective Clinical Trial
NOT YET RECRUITINGNCT07264894·PHASE4·Zhengzhou University·30 enrolled
ZSDT regimen
Obinutuzumab, Zanubrutinib, and Lenalidomide in First-line Treatment of Mantle Cell Lymphoma
NOT YET RECRUITINGNCT07261163·PHASE2·Institute of Hematology & Blood Diseases Hospital, China·37 enrolled
ZanubrutinibObinutuzumabLenalidomideCAR-T Cell Therapy
Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
NOT YET RECRUITINGNCT07225439·PHASE1·Paolo Caimi, MD·15 enrolled
Allogeneic NK cellsRituximabTafasitamabInterleukin-2Fludarabine/cyclophosphamide
Chemotherapy Combined With Targeted Therapy as First-line Treatment for Mantle Cell Lymphoma Based on MRD and PET-CT Assessment
NOT YET RECRUITINGNCT07206264·PHASE2·Tianjin Medical University Cancer Institute and Hospital·45 enrolled
Bendamustine + anti-CD20 monoclonal antibody/orelabrutinib + anti-CD20 monoclonal antibody
JWCAR239 in Patients With B Cell Non-Hodgkin Lymphoma
NOT YET RECRUITINGNCT07024147·PHASE1·Peking University Cancer Hospital & Institute·20 enrolled
JWCAR239FludarabineCyclophosphamide
A Prospective, Single-Center Study Evaluating the Efficacy and Safety of Glofitamab Combined With Orelabrutinib and Bortezomib in Patients With High-Risk Mantle Cell Lymphoma
NOT YET RECRUITINGNCT06656221·PHASE2·Ruijin Hospital·29 enrolled
ObinutuzumabGlofitamabBortezomibOrelabrutinib
Patient Perspectives in Mantle Cell Lymphoma Clinical Research
NOT YET RECRUITINGNCT06049472·Power Life Sciences Inc.·500 enrolled
This is a Phase II, Open-label, Multicentre Study of Zanubrutinib-containing Regimens in Patients With Newly Diagnosed Mantle Cell Lymphoma
NOT YET RECRUITINGNCT06427213·PHASE2·Henan Cancer Hospital·41 enrolled
Zanubrutinib,ObinutuzumabZanubrutinib and R-BAC
Linperlisib Plus Obinutuzumab and Venetoclax for Relapsed and Refractory Blastoid Variant of Mantle Cell Lymphoma.
NOT YET RECRUITINGNCT06324994·PHASE2·Dalian Medical University·10 enrolled
Linperlisib in combination with Obinutuzumab and Venetoclax
A Single-arm, Single-center, Open-label Phase II Study of Zanubrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle CellLymphoma Patients
NOT YET RECRUITINGNCT06255704·PHASE2·Shanxi Province Cancer Hospital·23 enrolled
Zanubrutinib and RCHOP/RDHAP
Study of PV in Combination With Bendamustine and Rituximab for Patients With R/R MCL
NOT YET RECRUITINGNCT04913103·PHASE2·Czech Lymphoma Study Group·21 enrolled
Polatuzumab vedotinBendamustine HydrochlorideRituximab
GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma
ACTIVE NOT RECRUITINGNCT06522386·PHASE2·M.D. Anderson Cancer Center·50 enrolled
PirtobrutinibRituximabVenetoclax
Study Evaluating SC262 in Subjects With r/r Non-Hodgkin's Lymphoma (VIVID)
ACTIVE NOT RECRUITINGNCT06285422·PHASE1·Sana Biotechnology·6 enrolled
SC262
Study of KTE-X19 in Adult Japanese Participants With Relapsed/Refractory Mantle Cell Lymphoma or Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
ACTIVE NOT RECRUITINGNCT06253663·PHASE2·Kite, A Gilead Company·25 enrolled
KTE-X19CyclophosphamideFludarabine
A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma
ACTIVE NOT RECRUITINGNCT06192888·PHASE1·Memorial Sloan Kettering Cancer Center·39 enrolled
GlofitamabObinutuzumabLenalidomide
A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma
ACTIVE NOT RECRUITINGNCT05951959·PHASE2·AstraZeneca·108 enrolled
AcalabrutinibVenetoclaxRituximab
Genetically Risk-Stratified Venetoclax, Ibrutinib, Rituximab (± Navitoclax) in Relapsed/Refractory Mantle Cell Lymphoma
ACTIVE NOT RECRUITINGNCT05864742·PHASE2·Peter MacCallum Cancer Centre, Australia·40 enrolled
IbrutinibVenetoclaxNavitoclaxRituximab
Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies
ACTIVE NOT RECRUITINGNCT05753501·PHASE1·AbbVie·135 enrolled
ABBV-101
Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)
ACTIVE NOT RECRUITINGNCT05878184·PHASE1·Sana Biotechnology·16 enrolled
SC291
Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies
ACTIVE NOT RECRUITINGNCT05665062·PHASE1·Synthekine·36 enrolled
SYNCAR-001STK-009CyclophosphamideFludarabine
A Study of Rocbrutinib in Participants With Relapse or Refractory Mantle Cell Lymphoma
ACTIVE NOT RECRUITINGNCT05716087·PHASE2·Guangzhou Lupeng Pharmaceutical Company LTD.·62 enrolled
Rocbrutinib
Biological Insights of First Relapsed-refractory Patients With Mantle Cell Lymphoma: the MANTLE-FIRST BIO Study.
ACTIVE NOT RECRUITINGNCT04882475·Fondazione Italiana Linfomi - ETS·160 enrolled