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Marco Ladetto

Associate Professor of Hematology, President of FIL

University of Eastern Piedmont / Azienda Ospedaliera SS Antonio e Biagio · Alessandria, Italy

About

Italian MCL expert and MRD pioneer. Has advanced molecular monitoring techniques in MCL and led Fondazione Italiana Linfomi MCL studies.

Specialties
MRD monitoringFrontline therapyTransplant
Key Trials
FIL MCL studies
Publications (14)

Evolving therapeutic strategies in mantle cell lymphoma: advancements and future directions.

Leukemia · Apr 15, 2026

Noninvasive genotyping and early disease dynamics demonstrate the efficacy of ibrutinib in combination with immunochemotherapy in patients with mantle cell lymphoma treated in the TRIANGLE trial.

Leukemia · Jan 1, 2026

Clinical impact of immunoglobulin heavy chain repertoire in mantle cell lymphoma: A study from the Fondazione Italiana Linfomi (FIL) Phase III MCL0208 trial.

HemaSphere · Jan 1, 2026

The integration of gene mutations and copy number variations refines the prognosis of mantle cell lymphoma: long-term results of the Fondazione Italiana Linfomi MCL0208 clinical trial.

Leukemia · Jan 1, 2026

Overcoming barriers to referral for CAR T-cell therapy in patients with non-Hodgkin aggressive B-cell lymphomas: A Delphi consensus.

Cytotherapy · Nov 1, 2025

Marked survival gains in patients ≤ 65 years with advanced-stage mantle cell lymphoma: a pooled analysis of six randomized phase III trials, 1996-2020.

Haematologica · Oct 30, 2025

Rituximab, bendamustine, and cytarabine followed by venetoclax in older patients with high-risk mantle cell lymphoma (FIL_V-RBAC): a multicentre, single-arm, phase 2 study.

The Lancet. Haematology · Oct 1, 2025

EHA-EU MCL network guidelines for diagnosis and treatment of mantle cell lymphoma.

HemaSphere · Oct 1, 2025

The MCL elderly III trial protocol: an international, randomized, open-label phase II trial to investigate the combinations of venetoclax, ibrutinib and rituximab or bendamustine, ibrutinib and rituximab in patients with treatment naive mantle cell lymphoma not eligible for dose-intensive treatment.

BMC cancer · Aug 25, 2025

Next-Generation Therapies in Mantle Cell Lymphoma (MCL): The Evolving Landscape in Treatment of Relapse/Refractory After CAR-T Cells.

Cancers · Jul 3, 2025

Large clones of clonal hematopoiesis affect outcome in mantle cell lymphoma: results from the FIL MCL0208 clinical trial.

Blood advances · Apr 22, 2025

Stem cell collection and hematological recovery in the Fondazione Italiana Linfomi (FIL) MCL0208 clinical trial.

Scientific reports · Jul 23, 2024

Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE): a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network.

Lancet (London, England) · May 25, 2024

Unmet needs in relapsed/refractory mantle cell lymphoma after failure of covalent Bruton's tyrosine kinase inhibitors: An Italian scenario.

Hematological oncology · Jan 1, 2024