Zanubrutinib
Brukinsa · BTKi · BTK
Second-generation covalent BTK inhibitor. Designed for higher BTK occupancy and reduced off-target binding.
Relapsed/refractory MCL
Clinical strategies for lymphoma management: Recommendations from the Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Consensus Conference 2025.
Cancer · Apr 2026
Bruton protein-tyrosine kinase (BTK) FDA-approved small molecule inhibitors used for the management of neoplastic and inflammatory disorders.
Pharmacological research · Apr 2026
Zanubrutinib-rituximab followed by shortened chemoimmunotherapy as frontline treatment for mantle cell lymphoma (CHESS): a phase II trial.
Nature communications · Mar 2026
Real-world comparative effectiveness of Bruton tyrosine kinase inhibitors in relapsed/refractory mantle cell lymphoma.
Blood advances · Mar 2026
A Meta-analysis Investigating Response Rates with Continuous Bruton Tyrosine Kinase Inhibitor Monotherapies in the Treatment of B Cell Lymphomas.
Oncology and therapy · Mar 2026
Efficacy and safety of zanubrutinib combined with age-adapted bendamustine and rituximab followed by zanubrutinib maintenance therapy in elderly patients with mantle cell lymphoma: a retrospective analysis.
Leukemia & lymphoma · Mar 2026
Cutaneous Adverse Effects in Patients Treated with BTK Inhibitors.
Cancers · Jan 2026
BTK Inhibition in Hematology: From CLL/SLL to Emerging Applications Across B-Cell and Immune Disorders.
Biomolecules · Jan 2026
Zanubrutinib mitigates pulmonary fibrosis in aged mice by targeting the Wnt/β-catenin signaling pathway.
Biochemical pharmacology · Jan 2026
Zanubrutinib versus acalabrutinib indirect treatment comparison in relapsed or refractory mantle cell lymphoma.
Leukemia & lymphoma · Dec 2025
Real-world treatment patterns of Bruton tyrosine kinase inhibitors in mantle cell lymphoma in a community oncology setting.
Future oncology (London, England) · Oct 2025
Hepatitis B virus reactivation in patients with hematologic malignancies treated with Bruton tyrosine kinase inhibitors.
Blood research · Aug 2025
Orally effective FDA-approved protein kinase targeted covalent inhibitors (TCIs): A 2025 update.
Pharmacological research · Jul 2025
Resistance Mechanism for Zanubrutinib in Marginal Zone Lymphoma.
Journal of the National Comprehensive Cancer Network : JNCCN · Jun 2025
Indirect Comparisons of Efficacy of Zanubrutinib Versus Orelabrutinib in Patients with R/R MCL: An Extended Follow-up Analysis.
Advances in therapy · Jun 2025
From development to clinical success: the journey of established and next-generation BTK inhibitors.
Investigational new drugs · Apr 2025
Evaluation of second-generation Bruton's tyrosine kinase inhibitors for the treatment of mantle cell lymphoma.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · Mar 2025
Covalent Bruton tyrosine kinase inhibitors across generations: A focus on zanubrutinib.
Journal of cellular and molecular medicine · Feb 2025
Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53 mutation.
Blood · Jan 2025
Establishment and Validation of a UPLC-MS/MS Method for Quantitative Determination of Zanubrutinib and Posaconazole in Rat Plasma: Application in Drug-Drug Interaction Studies.
Drug design, development and therapy · Jan 2025