MCL Literature Feed

A cross-validated, lymphoma-tailored NGS panel demonstrates high accuracy, providing a framework for implementing standardized genomic testing for prognostication in routine MCL clinical practice.

This systematic review finds all AI models for lymphoma histopathology, including MCL, have a high risk of bias, questioning their reported high accuracy and current clinical readiness.

A case of TP53-mutated, indolent non-nodal MCL suggests this high-risk marker may not mandate immediate therapy in this specific subtype, supporting a watch-and-wait approach.

A rare case of extranodal MCL presenting as bilateral adrenal masses showed avidity on both FDG and DOTATATE PET/CT, expanding the differential diagnosis for adrenal lesions.

This review clarifies that cyclin D1-negative MCL is driven by CCND2 or CCND3 translocations, proposing new terminology to improve diagnostic accuracy for this rare and often missed subtype.

Robotic-assisted bronchoscopy offers a safe, minimally invasive method for biopsying hard-to-reach aortopulmonary lymph nodes, as demonstrated in a case confirming MCL recurrence.

This case report describes a rare MCL relapse presenting as diabetes insipidus due to CNS involvement of the hypothalamus, highlighting an unusual manifestation of extranodal disease.

A rare case of MCL transdifferentiating into a clonally-related T-cell lymphoma demonstrates a novel transformation mechanism where B-cell markers are lost, complicating diagnosis at relapse.

This review highlights stereotyped B-cell receptors in MCL, suggesting common antigen-driven pathways that could provide a basis for molecular subclassification to refine patient risk stratification.

This methods paper details using sensitive qPCR and ddPCR to detect MRD in B-cell lymphomas by targeting Ig gene rearrangements and chromosomal translocations, relevant for MCL's t(11;14).

Mantle cell lymphoma can directly cause retinal vascular occlusion leading to ischemic retinopathy, a rare but vision-threatening extramedullary manifestation that clinicians should recognize.

This study confirms that low/negative CD200 and lower CD43 expression by flow cytometry reliably distinguish MCL from CLL, improving routine diagnostic accuracy for B-cell lymphoproliferative disorders.

This case report describes blastoid MCL presenting as an isolated cecal mass, highlighting an unusual clinical presentation and the need to consider lymphoma in the differential for GI tumors.

This pediatric pathology study is not relevant to mantle cell lymphoma; it repurposes the BCL-1/Cyclin D1 IHC stain to diagnose Hirschsprung disease, a non-malignant gastrointestinal disorder.

This case report details an exceptionally rare extranodal MCL presentation in the lacrimal drainage system, emphasizing its inclusion in the differential diagnosis for masses in this location.

This case report describes a hyperacute, aggressive presentation of small cell, non-nodal MCL, highlighting the clinical heterogeneity and challenging prognostic assumptions for this typically indolent subtype.

This case report describes an MCL diagnosis in a patient with mucous membrane pemphigoid, where frontline acalabrutinib and rituximab resolved both conditions, suggesting a paraneoplastic link.

A novel MIPI/CD3 prognostic model using Quantitative Dot Blot to measure T-cell infiltration improves risk stratification, showing high CD3+ T-cells correlate with better outcomes in MCL.

This case report of a non-MCL conjunctival lymphoma notes that MCL is a rare cause, highlighting an uncommon site of extranodal disease for MCL patients.

A case report of an elderly MCL patient with sequential relapses in rare extranodal sites (ocular adnexa, soft tissue, heart) highlights the need for vigilance for unusual disease presentations.

This case report details the rare co-occurrence of MCL and a tubular adenoma within a single colonic polyp, emphasizing the need for pathologists to carefully evaluate lymphoid aggregates in polyps.

This case report highlights how inadequate bone marrow sampling can lead to diagnostic errors, underscoring the critical need for proper technique to ensure accurate MCL staging and diagnosis.

Spontaneous splenic rupture is a rare but life-threatening initial presentation of MCL, requiring emergency splenectomy which can lead to the diagnosis, as highlighted by this case report.

Epigenetic profiling reveals a unique DNA methylation signature for B-cell prolymphocytic leukemia, providing a novel biomarker to differentiate it from its mimics, including mantle cell lymphoma.

This case report illustrates the diagnostic challenge of distinguishing mantle cell lymphoma from chronic lymphocytic leukemia, emphasizing the critical role of specific pathological and cytogenetic markers for accurate diagnosis.

In newly diagnosed MCL, PET/CT-based bone marrow assessment has greater prognostic value than biopsy and is incorporated into a new MCL-PET-I index for improved risk stratification.

This case report describes a rare MCL CNS relapse presenting as Horner syndrome and oculomotor nerve palsy, highlighting the need for CSF analysis in patients with atypical neurological symptoms, even with normal imaging.

This case report and literature review details the diagnosis and management of central nervous system involvement in MCL, a rare and aggressive manifestation with a poor prognosis.

This case report of non-nodal CNS MCL mimicking autoimmune or paraneoplastic encephalitis highlights the need to consider lymphoma in the differential diagnosis of complex neurological syndromes.

This case report demonstrates that MCL can cause severe renal failure via both direct infiltration and paraneoplastic glomerulonephritis, underscoring the need for kidney biopsy in unexplained nephropathy.